Data/hora: 12/06/2024 11:44:23

Provedor de dados: 	Biological Research	
País: 	Chile	
Título: 	Geobacillus stearothermophilus LV cadA gene mediates resistance to cadmium, lead and zinc in zntA mutants of Salmonella entérica serovar Typhimurium	
Autores: 	PÉREZ,JOSÉ M; PRADEÑAS,GONZALO A; NAVARRO,CLAUDIO A; HENRÍQUEZ,DANIEL R; PICHUANTES,SERGIO E; VÁSQUEZ,CLAUDIO C.	
Data: 	2006-01-01	
Ano: 	2006	
Palavras-chave: 	CadA; Cadmium; Lead; P-type ATPase; Zinc; ZntA.	
Resumo: 	Salmonella entérica serovar Typhimurium cells expressing the cadA gene of Geobacillus stearothermophilus LV exhibit a hypersensitive phenotype to cadmium chloride. Deletion of the ORF STM3576 from the Salmonella genome resulted in cadmium, lead and zinc sensitivity, confirming that this ORF is a homologue of the zntA gene. The observed sensitivity was reverted upon expression of the G. stearothermophilus LV cadA gene. These results indicate that the cadA gene product is involved in Cd, Pb and Zn resistance as a classical P-type ATPase and strongly suggest that the observed hypersensitive phenotype to these metals can be related to the function of the host ·zntA gene product	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500009	
Editor: 	Sociedad de Biología de Chile	
Formato: 	text/html	
Fonte: 	Biological Research  v.39 n.4 2006