Data/hora: 16/06/2024 06:53:32

Provedor de dados: | 49
País: | Brazil
Título: | Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins
Autores: | Agripino,Débora Gomes; Lima,Marcos Enoque Leite; Silva,Marcelo Rogério da; Meda,Cristiane Infante; Bolzani,Vanderlan da Silva; Cordeiro,Inês; Young,Maria Claudia Marx; Moreno,Paulo Roberto H.
Data: | 2004-01-01
Ano: | 2004
Palavras-chave: | Atlantic Rain forest; Antibacterial activity; Antifungal activity; Antitumoral activity; Plants screening.
Resumo: | I. Atlantic Rain Forest . Ecological Station Juréia-Itatins) Crude extracts from 88 plant species occurring in São Paulo State (Brazil), collected in an Atlantic Forest region, have been screened for antimicrobial and DNA-damaging activities. Of the 114 extracts assayed for antibacterial activity, only the extracts from leaves and stems of Aspidosperma ramiflorum (Apocynaceae) showed a slight activity against Escherichia coli. In the antifungal assay with Candida albicans, no active extract was observed, while in the bioautography assay with Cladosporium sphaerospermum and C. cladosporioides 12% were active. However, only the extract of Psychotria mapoureoides (Rubiaceae) stems showed a strong inhibition of both fungi. The DNA-damaging assay with mutant strains of Saccharomyces cerevisiae resulted in 17.5 % of active extracts. The majority (55 %) of the active extracts showed selectivity for the DNA-repair mechanism of topoisomerase II and only 20 % showed a selective response for the mechanism of topoisomerase I.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032004000200009
Editor: | Instituto Virtual da Biodiversidade | BIOTA - FAPESP
Relação: | 10.1590/S1676-06032004000200009
Formato: | text/html
Fonte: | Biota Neotropica  v.4 n.2 2004
Fonte: | info:eu-repo/semantics/openAccess