Data/hora: 08/06/2024 14:16:52

Provedor de dados: | 5
País: | France
Título: | Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas
Autores: | Schmitt, Paulina; De Lorgeril, Julien; Gueguen, Yannick; Destoumieux-garzon, Delphine; Bachere, Evelyne.
Data: | 2012-07
Ano: | 2012
Palavras-chave: | Pacific oyster; Bivalve mollusk; Innate immunity; Bactericidal/permeability-increasing protein; Proline-rich peptide; Defensin; Vibrio.
Resumo: | Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues. (c) 2012 Elsevier Ltd. All rights reserved.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/00093/20382/18267.pdf

DOI:10.1016/j.dci.2012.01.004

Editor: | Elsevier Sci Ltd
Relação: | http://archimer.ifremer.fr/doc/00093/20382/
Formato: | application/pdf
Fonte: | Developmental And Comparative Immunology (0145-305X) (Elsevier Sci Ltd), 2012-07 , Vol. 37 , N. 3-4 , P. 363-370
Fonte: | 2012 Elsevier Ltd. All rights reserved.