Data/hora: 05/06/2024 11:47:13

Provedor de dados: | 5
País: | France

Título:

La métabolomique et les biotoxines marines

Metabolomics and marine biotoxins

Autores: | Mondeguer, Florence.
Data: | 2016-09
Ano: | 2016
Palavras-chave: | Biotoxines; Biomarqueurs; Métabolomique; Microalgues; Moules; Spectrométrie de masse haute résolution (HRMS); Workflow.
Resumo: | Metabolomics is a new approach to assess the contamination of organisms, environmental compartments or foodstuffs, and the impact marine pollution, (natural or anthropogenic), can have on them. Through the analysis of the variation of the metabolite profiles present in the cell, tissues, organs or even the whole organism it is possible to define a physiological state, a stage of development, or the level and nature of a contamination. Generally, analysis of metabolites correlates to experimental design built around a clear biological or environmental question, needs to be supported by sensitive and reproducible tools, and requires access to libraries "house" or international. Often, the non-targeted approach allows for evaluation of many hypotheses. Thus, it is possible to explain how exposure to chemical pollutants such as lead, may cause neurotoxicity, disruptions in the energy metabolism, osmotic changes or disturbance in lipid metabolism. Some studies have shown that the metabolic disturbances associated with the combination of drugs and environmental toxicants often appeared much earlier than other changes induced by pollution (15). Nevertheless, as is clear from these three articles, the potential answer given is based on the power of the tools used, the more techniques are integrated into the approach, the more it is balanced and the easier biosynthetic pathways will be understood. Only orthogonal workflows allow for the holistic detection of the metabolome, including compounds produced in trace quantities which may nonetheless be essential to the understanding of biosynthetic mechanisms. Another important advantage of non-targeted HRMS analysis is that, if used in conjunction with a well-managed archive, it provides for retrospective studies that may help define the emergence of contaminants.
Tipo: | Text
Idioma: | Francês

Identificador:

http://archimer.ifremer.fr/doc/00358/46892/46777.pdf

http://archimer.ifremer.fr/doc/00358/46892/

Editor: | Anses
Formato: | application/pdf
Fonte: | Bulletin de veille scientifique (1950-4764) (Anses), 2016-09 , N. 29 , P. 61-64

Fonte:

Anses Éditions

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