Data/hora: 09/06/2024 00:45:33

Provedor de dados: 	5	
País: 	France	
Título: 	Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (Dicentrarchus labrax)	
Autores: 	Villeneuve, Laure; Gisbert, Enric; Moriceau, Jacques; Cahu, Chantal; Zambonino, Jose-luis.	
Data: 	2006-04	
Ano: 	2006	
Palavras-chave: 	Retinoid pathway; Morphogenesis; Vitamin A; PUFA; Sea bass larvae.	
Resumo: 	The effect of the feeding period on larval development was investigated in European sea bass larvae by considering the expression level of some genes involved in morphogenesis. Larvae were fed a control diet except during three different periods (period A: from 8 to 13 d post-hatching (dph); period B: from 13 to 18 dph; period C: from 18 to 23 dph) with two compound diets containing high levels of vitamin A or PUFA. European sea bass morphogenesis was affected by these two dietary nutrients during the early stages of development. The genes involved in morphogenesis could be modulated between 8 and 13 dph, and our results indicated that retinoids and fatty acids influenced two different molecular pathways that in turn implicated two different gene cascades, resulting in two different kinds of malformation. Hypervitaminosis A delayed development, reducing the number of vertebral segments and disturbing bone formation in the cephalic region. These malformations were correlated to an upregulation of retinoic acid receptor gamma, retinoid X receptor (RXR) alpha and bone morphogenetic protein (BMP)4. An excess of PUFA accelerated the osteoblast differentiation process through the upregulation of RXR alpha and BMP4, leading to a supernumerary vertebra. These results suggest that the composition of diets devoted to marine fish larvae has a particularly determining effect before 13 dph on the subsequent development of larvae and juvenile fish.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/2006/publication-1215.pdf

DOI:10.1079/BJN20051668	
Editor: 	CABI	
Relação: 	http://archimer.ifremer.fr/doc/00000/1215/	
Formato: 	application/pdf	
Fonte: 	British Journal of Nutrition (0007-1145) (CABI), 2006-04 , Vol. 95 , N. 4 , P. 677-687	
Fonte: 	2006 CABI Publishing