Data/hora: 08/06/2024 09:29:30

Provedor de dados: | Institutional Archive of Ifreme (ArchiMer)
País: | France
Título: | Evolution of gene dosage on the Z-chromosome of schistosome parasites
Autores: | Picard, Marion A. L.; Cosseau, Celine; Ferre, Sabrina; Quack, Thomas; Grevelding, Christoph G.; Coute, Yohann; Vicoso, Beatriz.
Data: | 2018-07
Ano: | 2018
Resumo: | XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary strata. We use these to assess gene expression evolution following sex-linkage. The resulting patterns suggest a reduction in expression of Z-linked genes in females, combined with upregulation of the Z in both sexes, in line with the first step of Ohno's classic model of dosage compensation evolution. Quantitative proteomics suggest that post-transcriptional mechanisms do not play a major role in balancing the expression of Z-linked genes.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00454/56588/71845.pdf

DOI:10.7554/eLife.35684

https://archimer.ifremer.fr/doc/00454/56588/

Editor: | Elife Sciences Publications Ltd
Formato: | application/pdf
Fonte: | Elife (2050-084X) (Elife Sciences Publications Ltd), 2018-07 , Vol. 7 , N. e35684 , P. 36p.

Fonte:

info:eu-repo/semantics/openAccess

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