Data/hora: 08/06/2024 02:10:13

Provedor de dados: | Institutional Archive of Ifreme (ArchiMer)
País: | France
Título: | Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections
Autores: | Moreau, Pierrick; Moreau, Kevin; Segarra, Amelie; Tourbiez, Delphine; Travers, Marie-agnes; Rubinsztein, David C.; Renault, Tristan.
Data: | 2015-03
Ano: | 2015
Palavras-chave: | Autophagy; Crassostrea gigas; OsHV-1; Pacific oyster; Vibrio aestuarianus; ATG; Autophagy-related; Atg8-PE; Atg8-phosphatidylethenolamine; DNA; Deoxyribonucleic acid; Hpi; Hours postinfection; LC3-II; Cleaved; Lipidated and autophagosome-associated form of LC3; MAP1LC3A; B (LC3A; B); Microtubule-associated proteins 1 light chain 3 alpha.
Resumo: | Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/00269/37989/36072.pdf

DOI:10.1080/15548627.2015.1017188

http://archimer.ifremer.fr/doc/00269/37989/

Editor: | Taylor &amp; Francis Inc
Relação: | info:eu-repo/grantAgreement/EC/FP7/266157/EU//BIVALIFE
Formato: | application/pdf
Fonte: | Autophagy (1554-8627) (Taylor &amp; Francis Inc), 2015-03 , Vol. 11 , N. 3 , P. 516-526

Fonte:

2015 The Author(s). Published with license by Taylor &amp; Francis Group, LLC

info:eu-repo/semantics/openAccess

restricted use