Data/hora: 05/06/2024 09:09:56

Provedor de dados: | 5
País: | France
Título: | (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
Autores: | Cosseau, Celine; Wolkenhauer, Olaf; Padalino, Gilda; Geyer, Kathrin K.; Hoffmann, Karl F.; Grunau, Christoph.
Data: | 2017-04
Ano: | 2017
Resumo: | The GxE concept, in which genotype x environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00385/49607/71826.pdf

https://archimer.ifremer.fr/doc/00385/49607/71827.pdf

DOI:10.1016/j.pt.2016.12.002

https://archimer.ifremer.fr/doc/00385/49607/

Editor: | Elsevier Sci Ltd
Formato: | application/pdf
Fonte: | Trends In Parasitology (1471-4922) (Elsevier Sci Ltd), 2017-04 , Vol. 33 , N. 4 , P. 285-294

Fonte:

info:eu-repo/semantics/openAccess

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