Data/hora: 05/06/2024 03:01:20

Provedor de dados: 	5	
País: 	France	
Título: 	Modelling of paralytic shellfish toxin biotransformations in the course of Crassostrea gigas detoxification kinetics	
Autores: 	Gueguen, Marielle; Baron, Regis; Bardouil, Michele; Truquet, Philippe; Haberkorn, Hansy; Lassus, Patrick; Barille, Laurent; Amzil, Zouher.	
Data: 	2011-09	
Ano: 	2011	
Palavras-chave: 	Detoxification kinetics modelling; Biotransformation of saxitoxin analogues; Oyster.	
Resumo: 	The aim of this study was to evaluate the importance of biotransformation of paralytic shellfish toxins during the detoxification process in contaminated oysters. Mathematical models based upon the detoxification patterns of digestive gland and other tissues were developed. It was demonstrated that biotransformations do not seem to play an important role in digestive gland or other tissue detoxification kinetics with our data set. Moreover, different toxin transfers from digestive gland toward other tissues were investigated. No significant transfer was highlighted in our data set. These first conclusions were drawn after comparing the results obtained from 13 biotransformations and identifiable transfer scenarios. Finally, to determine a more robust model, all 12 states corresponding to toxic compounds and tissues were aggregated into a single state model. The best adjustment was obtained with a simple one-compartment model based on total flesh toxicity with elimination rate expressed by a function depending on initial concentrations of GTX3 and GTX2 (i.e. the two major toxic compounds found in contaminated oysters). (C) 2011 Elsevier B.V. All rights reserved.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/00049/16047/14309.pdf

DOI:10.1016/j.ecolmodel.2011.07.007	
Editor: 	Elsevier Science Bv	
Relação: 	http://archimer.ifremer.fr/doc/00049/16047/	
Formato: 	application/pdf	
Fonte: 	Ecological Modelling (0304-3800) (Elsevier Science Bv), 2011-09 , Vol. 222 , N. 18 , P. 3394-3402	
Fonte: 	2011 Elsevier B.V. All rights reserved.