Data/hora: 09/06/2024 11:34:14

Provedor de dados: 	Institutional Archive of Ifreme (ArchiMer)	
País: 	France	
Título: 	Vibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition	
Autores: 	Bruto, Maxime; James, Adele; Petton, Bruno; Labreuche, Yannick; Chenivesse, Sabine; Alunno-bruscia, Marianne; Polz, Martin F.; Le Roux, Frederique.	
Data: 	2017-04	
Ano: 	2017	
Resumo: 	Vibrios are frequently associated with oyster mortality; however whether they are the primary causative agent or secondary opportunistic colonizers is not well understood. Here we combine analysis of natural infection dynamics, population genomics and molecular genetics to ask (i) to what extent oysters are passively colonized by Vibrio population present in the surrounding water, (ii) how populations turn over during pathogenicity events and (iii) what genetic factors are responsible for pathogenicity. We identified several populations of Vibrio preferentially associated with oyster tissues. Among these, Vibrio crassostreae is particularly abundant in diseased animals while nearly absent in the surrounding water, and its pathogenicity is correlated with the presence of a large mobilizable plasmid. We further demonstrate that the plasmid is essential for killing but not necessary for survival in tissues of oysters. Our results suggest that V. crassostreae first differentiated into a benign oyster colonizer that was secondarily turned into a pathogen by introgression of a virulence plasmid into the population, possibly facilitated by elevated host density in farming areas.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/00360/47137/49044.pdf

DOI:10.1038/ismej.2016.162

http://archimer.ifremer.fr/doc/00360/47137/	
Editor: 	Nature Publishing Group	
Formato: 	application/pdf	
Fonte: 	Isme Journal (1751-7362) (Nature Publishing Group), 2017-04 , Vol. 11 , N. 4 , P. 1043-1052	
Fonte: 	2016 International Society for Microbial Ecology All rights reserved

info:eu-repo/semantics/openAccess

restricted use