Data/hora: 18/06/2024 07:35:37

Provedor de dados: | 5
País: | France
Título: | Préparation, caractérisation et activités biologiques de fucanes extraits d'algues brunes
Autores: | Colliec Jouault, Sylvia.
Data: | 1990-01-12
Ano: | 1990
Resumo: | Fucoldans are a family of high molecular weight sulfated polysaccharides (from 8x105 to 1 x106 g/mol) widely dispersed in brown seaweed cell wall. When extracted from several brown algae, they exhibit anticoagulant properties. The chemical degradation of a crude extract, from Pelvetia canaliculata undertaken to obtain a low molecular weight polysaccharide (4 x 104 g/mol) with the purpose of a possible clinical use. Its anticoagulant potency was investigated through the inhibition of factor IIa and factor Xa in the presence of antithrombin III or heparin cofactor II. The degraded fucoidan revealed a potent antithrombin activity, although weaker than heparin. In the presence of either antithrombin III depleted plasma or purified heparin cofactor II, the fucoidan was as efficient as heparin or dermatan sulfate on heparin cofactor II potentiation, at the same ponderal concentration. In whole plasma or in presence of the purified inhibitor, an inhibition of factor Ila activity mediated by antithrombin III was detected (30 times less potent than heparin, on a weight to weight basis). No inhibition of factor Xa activity was detected in the same experimental conditions, Chemical degradations of various crude extracts, from four brown seaweeds; have given low molecular weight fucoidan fractions (almost 2 x 104 g/mol). In plasma or in presence of purified heparin cofactor II, these fractions have revealed a same anticoagulant activity and mode of action that the previous fraction extracted from Pelvetia canaliculata. These fucoidans, by-products of alginates preparation in the food and cosmetologic industries, are obtained easily. Thus, they may represent a cheap and easy source of a new type of anticoagulants.
Tipo: | Text
Idioma: | Francês

Identificador:

https://archimer.ifremer.fr/doc/00651/76332/77320.pdf

https://archimer.ifremer.fr/doc/00651/76332/

Editor: | Université Paris-Nord
Formato: | application/pdf

Fonte:

info:eu-repo/semantics/openAccess

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