Data/hora: 04/06/2024 00:34:18

Provedor de dados: | 5
País: | France
Título: | Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
Autores: | Longeon, Arlette; Copp, Brent R.; Quevrain, Elodie; Roue, Melanie; Kientz, Betty; Cresteil, Thierry; Petek, Sylvain; Debitus, Cecile; Bourguet-kondracki, Marie-lise.
Data: | 2011-05
Ano: | 2011
Palavras-chave: | Indole derivatives; Bromoindoles; Marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA(2) inhibitor; Antioxidant; Cytotoxic.
Resumo: | Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00214/32485/30975.pdf

DOI:10.3390/md9050879

https://archimer.ifremer.fr/doc/00214/32485/

Editor: | Mdpi Ag
Formato: | application/pdf
Fonte: | Marine Drugs (1660-3397) (Mdpi Ag), 2011-05 , Vol. 9 , N. 5 , P. 879-888

Fonte:

2011 MDPI AG (Basel, Switzerland) unless otherwise stated

info:eu-repo/semantics/openAccess

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