Data/hora: 08/06/2024 10:09:41

Provedor de dados: | 5
País: | France
Título: | Projet de recherche sur l'identification de nouveaux composés toxiques dans les coquillages
Autores: | Amzil, Zouher.
Data: | 1996-09
Ano: | 1996
Palavras-chave: | Toxicité atypique; Test-souris; Neurotoxicité; Identification de principe(s) actif(s); Atypical toxicity; Mouse-test; Neurotoxicity; Identification of active principle( s).
Resumo: | ln November 1992, an event affecting Shellfish health received extensive media coverage: an unknown toxin had been detected in oysters from the bay of MarennesOleron (France). This phenomenon remains unexplained to this day. Since then, a growing number of observations obtained in the context of the REPHY phytoplankton monitoring network, have reported a mouse-active substance found in Shellfish and belonging to none of the known phycotoxin classes. These observations have been reported in France as weil as abroad (Canada, Norway, Ireland, New Zealand ... ). Mice treated intraperitoneally with the DSP screening test- exhibit neurological symptoms with disorders of the central nervous system leading to early death (within 5 to 10 minutes). Several hundred kilograms of contaminated Shellfish are now kept in storage and the Phycotoxins &amp; Nuisances Laboratory at IFREMER Department of Coastal Environment has initiated a research program in an attempt to identify the active principle. After isolation of the pure toxin, we will th en move on to the toxicological studies required to elucidate the mode of action of this substance and to assess its health impact. Once we have gained knowledge of the chemical nature and toxicological properties of the compound implicated, it will then become possible to develop methods of physicochemical and/or biological analysis based on criteria of specificity, speed and reliability.
Tipo: | Text
Idioma: | Francês
Identificador: | http://archimer.ifremer.fr/doc/00156/26732/24813.pdf
Relação: | http://archimer.ifremer.fr/doc/00156/26732/
Formato: | application/pdf
Fonte: | 1996 Ifremer