Data/hora: 01/06/2024 18:31:24

Provedor de dados: | Institutional Archive of Ifreme (ArchiMer)
País: | France
Título: | Exopolysaccharides Isolated from Hydrothermal Vent Bacteria Can Modulate the Complement System
Autores: | Courtois, Anthony; Berthou, Christian; Guezennec, Jean; Boisset, Claire; Bordron, Anne.
Data: | 2014-04
Ano: | 2014
Resumo: | The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be depolymerised. Furthermore, the over-sulphation of EPSs can modify their biological activity. The aim of this study was to investigate the immunodulation of the complement system by either native or over-sulphated low molecular weight EPSs isolated from vent bacteria in order to find pro or anti-activators of complement.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/00198/30963/29337.pdf

DOI:10.1371/journal.pone.0094965

Editor: | Public Library Science
Relação: | http://archimer.ifremer.fr/doc/00198/30963/
Formato: | application/pdf
Fonte: | Plos One (1932-6203) (Public Library Science), 2014-04 , Vol. 9 , N. 4 , P. e94965
Fonte: | 2014 Courtois et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.