Data/hora: 29/05/2024 05:39:03

Provedor de dados: 	Institutional Archive of Ifreme (ArchiMer)	
País: 	France	
Título: 	A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster,  Crassostrea gigas	
Autores: 	Lafont, Maxime; Vergnes, Agnes; Vidal-dupiol, Jeremie; De Lorgeril, Julien; Gueguen, Yannick; Haffner, Philippe; Petton, Bruno; Chaparro, Cristian; Barrachina, Celia; Destoumieux-garzon, Delphine; Mitta, Guillaume; Gourbal, Benjamin; Montagnani, Caroline.	
Data: 	2020-04	
Ano: 	2020	
Palavras-chave: 	Innate immunity; Priming; OsHV-1; Antiviral response; Immune memory; Oyster; POMS; Poly(I·C); Interferon; Transcriptomic.	
Resumo: 	Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster Crassostrea gigas. Oysters were fully protected against Ostreid herpesvirus 1 (OsHV-1), a major oyster pathogen, after priming with poly(I·C), which mimics viral double-stranded RNA. Global analysis through RNA sequencing of oyster and viral genes after immune priming and viral infection revealed that poly(I·C) induces a strong antiviral response that impairs OsHV-1 replication. Protection is based on a sustained upregulation of immune genes, notably genes involved in the interferon pathway and apoptosis, which control subsequent viral infection. This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired resistance mechanism reinforces the molecular foundations of the sustained response model of immune priming. It further opens the way to applications (pseudovaccination) to cope with a recurrent disease that causes dramatic economic losses in the shellfish farming industry worldwide.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00614/72580/71541.pdf

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DOI:10.1128/mBio.02777-19

https://archimer.ifremer.fr/doc/00614/72580/	
Editor: 	American Society for Microbiology	
Relação: 	info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI	
Formato: 	application/pdf	
Fonte: 	mBio (2150-7511) (American Society for Microbiology), 2020-04 , Vol. 11 , P. e02777-19 (17p.)	
Fonte: 	info:eu-repo/semantics/openAccess

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