Data/hora: 17/06/2024 14:56:03

Provedor de dados: | 5
País: | France
Título: | Marine Exopolysaccharide Complexed with Scandium Aimed as Theranostic Agents
Autores: | Mazza, Mattia; Alliot, Cyrille; Sinquin, Corinne; Colliec-jouault, Sylvia; Reiller, Pascal E.; Huclier-markai, Sandrine.
Data: | 2021-02
Ano: | 2021
Palavras-chave: | Exopolysaccharides; Scandium; Theranostic; Characterization; Complexation.
Resumo: | Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. (3) Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. (4) Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00681/79332/81844.pdf

DOI:10.3390/molecules26041143

https://archimer.ifremer.fr/doc/00681/79332/

Editor: | MDPI AG
Formato: | application/pdf
Fonte: | Molecules (1420-3049) (MDPI AG), 2021-02 , Vol. 26 , N. 4 , P. 1143 (23p.)

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