Data/hora: 11/06/2024 06:36:48

Provedor de dados: | Institutional Archive of Ifreme (ArchiMer)
País: | France

Título:

Etude des interactions hôte/virus chez l’huître creuse Crassostrea gigas et son virus Ostreid herpesvirus 1

Studying interaction between the Pacific oyster, Crassostrea gigas, and Ostreid herpesvirus type 1

Autores: | Segarra, Amelie.
Data: | 2014-11-14
Ano: | 2014
Palavras-chave: | Bivalves; Huître creuse; Crassostrea gigas; Mortalités; OsHV-1; Gènes viruax; Interaction hôte-virus; Transcriptome; Sensibilité; PCR en temps réel; Bivalve; Pacific oyster; Crassostrea ggias; Mortality; OsHV-1; Viral gene; Interaction host-virus; Transcriptome; Susceptibility; Real-time PCR.
Resumo: | Ostreid herpesvirus type 1 (OsHV-1) can be considered one of the major infectious agents in Pacific oysters, Crassostrea gigas, in France and all around the world. Differences in terms of mortality among infected animals were reported suggesting a genetic basis of the susceptibility to the OsHV-1 infection. In this context, the main objective of this thesis was to understand the interactions between Pacific oysters and OsHV-1, in particular, the molecular basis of the viral cycle. Results showed that the virus is able to replicate in the host regardless of its stage of development or its susceptibility. However, multiplication kinetics is faster in the most susceptible individuals compared to less susceptible ones. After an active replication phase, it would appear that the virus is no detectable in survival individuals. This observation suggests (i) a remission with elimination of the virus or (ii) virus persistence without detectable symptoms. These results highlight the ability of the virus circulating in the host without causing mortality. These individuals can excrete viral particles and interfere with the infection process in the field. Genes that could be involved in antiviral defenses were also identified in Pacific oysters (IFI44, IAP, glypican, …). All these results represent a first contribution to the understanding of OsHV-1 cycle in Pacific oysters, particularly at the molecular level.
Tipo: | Text
Idioma: | Francês

Identificador:

http://archimer.ifremer.fr/doc/00252/36297/34826.pdf

http://archimer.ifremer.fr/doc/00252/36297/

Editor: | Université de Bretagne-Sud
Relação: | info:eu-repo/grantAgreement/EC/FP7/266157/EU//BIVALIFE
Formato: | application/pdf

Fonte:

2014 UEB

info:eu-repo/semantics/openAccess

restricted use