Data/hora: 17/06/2024 02:33:53

Provedor de dados: | 5
País: | France
Título: | Dietary exposure of juvenile common sole (Solea solea L.) to polybrominated diphenyl ethers (PBDEs): Part 2. Formation, bioaccumulation and elimination of hydroxylated metabolites
Autores: | Munschy, Catherine; Moisan, Karine; Tixier, Celine; Pacepavicius, G.; Alaee, M.
Data: | 2010-12
Ano: | 2010
Palavras-chave: | Marine flatfish; PBDEs; Bioaccumulation; Biotransformation; Hydroxylated metabolites.
Resumo: | The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea L) exposed to spiked contaminated food over a three-month period, and then depurated over a five-month period. Methoxylated (MeO-) and hydroxylated (OH-) PBDEs were determined in fish plasma exposed to PBDEs and compared to those obtained in control fish. While all MeO- and some OH- congeners identified in fish plasma were found to originate from non-metabolic sources, several OH- congeners, i.e., OH-tetraBDEs and OH-pentaBDEs, were found to originate from fish metabolism. Among these, 4 '-OH-BDE-49 was identified as a BDE-47 metabolite. Congener 4 '-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. Our results unequivocally showed that PBDEs are metabolised in juvenile sole via the formation of OH- metabolites. However, this was not a major biotransformation route compared to biotransformation through debromination. (C) 2010 Elsevier Ltd. All rights reserved.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/00017/12811/11295.pdf

DOI:10.1016/j.envpol.2010.08.021

Editor: | Elsevier Sci Ltd
Relação: | http://archimer.ifremer.fr/doc/00017/12811/
Formato: | application/pdf
Fonte: | Environmental Pollution (0269-7491) (Elsevier Sci Ltd), 2010-12 , Vol. 158 , N. 12 , P. 3527-3533
Fonte: | 2010 Elsevier Ltd All rights reserved.