Data/hora: 03/06/2024 18:44:22

Provedor de dados: | 52
País: | Brazil
Título: | Combination vitamin C and vitamin E prevents enteric diabetic neuropathy in the small intestine in rats
Autores: | Zanoni,Jacqueline Nelisis; Hermes-Uliana,Catchia.
Data: | 2015-08-01
Ano: | 2015
Palavras-chave: | Ascorbic acid; Α-tocopherol; Diabetes mellitus; Myenteric plexus; Enteric nervous system.
Resumo: | The present study evaluated the effects of supplementation with a combination of vitamin C and vitamin E on NADH-diaphorase-positive (NADH-d+) and neuronal nitric oxide synthase (nNOS)-immunoreactive myenteric neurons in the duodenum and ileum in diabetic rats. Forty rats were distributed into the following groups: normoglycemic (N), normoglycemic supplemented with vitamin C and vitamin E (NS), diabetic (D), and diabetic supplemented with vitamin C and vitamin E (DS). Vitamin C was added to the drinking water, and vitamin E was incorporated in the diet (1%). After 120 days, the animals were euthanized, and the duodenum and ileum were subjected to NADH-d and nNOS staining. Quantitative and morphometric analyses of myenteric neurons were performed. Diabetes reduced NADH-d+ neurons in the D group. The density of nitrergic neurons was not changed by diabetes or vitamin treatment. Hypertrophy of the cell body area of NADH-d+ and nNOS-immunoreactive neurons was observed in both intestinal segments. Combined supplementation with vitamin C and vitamin E prevented the reduction of the density of NADH-d+ neurons and hypertrophy, demonstratred by both techniques. Supplementation with a combination of vitamin C and vitamin E promoted myenteric neuroprotection in the small intestine in diabetic rats.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400504
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-8913201500414
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.58 n.4 2015
Fonte: | info:eu-repo/semantics/openAccess