Data/hora: 17/06/2024 12:51:20

Provedor de dados: | 52
País: | Brazil
Título: | Methotrexate inhibits integrin adhesion molecules in the mouse model of pleurisy induced by carrageenan
Autores: | Dalmarco,Eduardo Monguilhott; Fröde,Tânia Silvia.
Data: | 2007-09-01
Ano: | 2007
Palavras-chave: | Methotrexate; CD11a/CD18 adhesion molecules; Leukocyte migration; Pleurisy; Mice.
Resumo: | The aim of this work was to analyze the effect of methotrexate (MTX) upon leukocyte migration and expression of adhesion molecules CD11a/CD18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. The results showed that MTX significantly decreased leukocyte influx and CD11a expression in the lung at 4 and 48 h of pleurisy (P &lt; 0.01). MTX also inhibited CD18 expression at 4 h but not 48 h of pleurisy (P &lt; 0.01). These results proved that MTX at the studied doses had important anti-inflammatory properties, acting primarily on leukocyte migration from the pleural cavity to the lung via inhibition of CD11a/CD18 expression in the mouse model of inflammation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500005
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132007000500005
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.50 n.5 2007
Fonte: | info:eu-repo/semantics/openAccess