Data/hora: 09/06/2024 04:04:29

Provedor de dados: 	Brazilian Archives of Biology and Technology	
País: 	Brazil	
Título: 	Human FcRn can mediate the transport across intestinal mucosal barrier and prolong the half-life of rabbit IgG in vivo	
Autores: 	Pang,Guangchang; Wang,Yufang; Xie,Junbo; Chen,Qingsen; Hu,Zhihe.	
Data: 	2015-06-01	
Ano: 	2015	
Palavras-chave: 	FcRn; Heterogeneous IgG transport; Complement fixation test; FcγR; Gastrointestinal barrier.	
Resumo: 	FcRn (neonatal Fc receptor) plays an important role in IgG transportation, antigen presentation and signal transmission. In this study, the complement fixation test and flow cytometry test were performed to verify whether the heterologous antibody could be transmitted to the serum or leukocyte with FcγR (Fc gamma receptor) across the intestinal mucosa. The results showed that rabbit anti-bovine IgG could be detected in both the serum and the leukocytes, which indicated that the heterologous antibody could transport across the intestinal mucosa to enter the blood and be effectively delivered to the leukocytes with FcγR. In addition, the results also showed that the rabbit anti-bovine IgG still could be detected in the leukocyte group (P=0.044&lt;0.05) after 21 days. It indicated that the rabbit IgG could exist in the body for a long term (up to 21 days) after being transported to the cells containing FcγR.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300387	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/S1516-8913201500035	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.58 n.3 2015	
Fonte: 	info:eu-repo/semantics/openAccess