Data/hora: 06/06/2024 18:45:07

Provedor de dados: 	52	
País: 	Brazil	
Título: 	Effect of mannitol on the pharmacokinetics of amikacin in wistar rats	
Autores: 	Olguín,Hugo Juárez; Portugal,Miriam Carrasco; Pérez,Janett Flores; Vieyra,Angélica Camacho; Pérez,Carmen Flores; Rodríguez,Alfonso Alfaro.	
Data: 	2009-08-01	
Ano: 	2009	
Palavras-chave: 	Pharmacokinetics; Interactions; Amikacin; Mannitol; Antibiotics; Diuretics.	
Resumo: 	The study analyzed the effect of mannitol on the pharmacokinetics (PK) of amikacin. Adult Wistar rats were treated as follows: Group 1 (G1) received mannitol for three days, Group 2 (G2) received mannitol plus 10 mg/kg of amikacin simultaneously, and Group 3 only amikacin. The PK study was conducted on the 4th day. For which, blood samples were drawn at fixed times during 24 h and immunoenzymatically analyzed. Results revealed significant differences (p&lt;0.05) between the groups, e.g. Cmax were 62.26 ± 15.75 µg/ml for G1, 72.63 ± 24.80 µg/ml for G2 and 68.61 ± 27.40 µg/ml for G3. The AUC also differed in the three groups, being largest for G2, 222.52 ± 47.30 µg/ml/h, and smallest for G1, 135.59 ± 39.00 µg/ml/h. Alteration of the PK parameters observed between the groups must be considered when both drugs are prescribed, although human studies are necessary to confirm the results.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400006	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/S1516-89132009000400006	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.52 n.4 2009	
Fonte: 	info:eu-repo/semantics/openAccess