Data/hora: 12/06/2024 13:49:51

Provedor de dados: | Brazilian Archives of Biology and Technology
País: | Brazil
Título: | Ethanol affects the absorption and tissue distribution of orally administered antigens in mice
Autores: | Oliveira,Flávia Márcia; Gusmão,Leandro José; Cardoso,Valbert do Nascimento; Ramaldes,Gilson Andrade; Ruiz-de-Souza,Valéria; Gontijo,Cristiano Machado.
Data: | 2013-08-01
Ano: | 2013
Palavras-chave: | Ethanol; Absorption; Biodistribution; Technetium; Immune response.
Resumo: | The aim of this work was to evaluate the effects of ethanol on the adsorption and tissue distribution of orally administered antigens in mice. Results showed that ethanol reduced the level of anti-ovalbumin IgA antibodies in intestinal fluid for the mice treated orally with a palmitoyl-ovalbumin conjugate. Ethanol was administered intragastrically to mice at 5 g/kg body weight for 14 days (chronic treatment), or 10 g/kg body weight every 7th day up to 14 days (acute treatment). Thereafter, 99m technetium-labeled antigens were administered and lymphoid tissues were collected. Ethanol interfered with the transport of ovalbumin to the liver. Moreover, the transport of palmitoyl-ovalbumin to mesenteric lymph nodes was reduced 6 h after the antigen administration. In conclusion, there was a relationship between the suppression of ethanol-mediated specific local IgA responses and the decreased transport of palmitoyl-ovalbumin to mesenteric lymph nodes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000400008
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132013000400008
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.56 n.4 2013
Fonte: | info:eu-repo/semantics/openAccess