Data/hora: 09/06/2024 03:51:00

Provedor de dados: | 52
País: | Brazil
Título: | Influence of tetracycline in the hepatic and renal development of rat's offspring
Autores: | Machado,Ana Lourdes da Silva; Brandão,Adriana Aigotti Haberbeck; Silva,Cláudia Maria de Oliveira Monteiro da; Rocha,Rosilene Fernandes da.
Data: | 2003-01-01
Ano: | 2003
Palavras-chave: | Pregnancy; Development; Tetracycline; Hepatotoxicity; Nephrotoxicity.
Resumo: | This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000100008
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132003000100008
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.46 n.1 2003
Fonte: | info:eu-repo/semantics/openAccess