Data/hora: 10/06/2024 16:14:08

Provedor de dados: | Brazilian Archives of Biology and Technology
País: | Brazil
Título: | Antidepressant effects of standardized extract of Commiphora mukul Engl. in olfactory bulbectomized rats
Autores: | Kalshetti,Padmaja Bhimashankar; Alluri,Ramesh; Thakurdesai,Prasad Arvind.
Data: | 2015-02-01
Ano: | 2015
Palavras-chave: | Antidepressant Activity; Commiphora MukulEngl; Guggul; Olfactory Bulbectomy Model.
Resumo: | The objective of this work was to evaluate the effects of standardized hydroalcholic extract of Commiphora mukul (HECM) in animal model of chronic stress medicated depression, namely olfactory bulbectomy (OBX) model in rats. Effects of 14-day (subacute) oral pretreatment of HECM (50, 100 and 200 mg/kg) were evaluated on depression and stress related parameters on OBX rats. Separate groups for sham control, OBX control and positive controls namely imipramine (20 mg/kg), fluoxetine (30 mg/kg) and desipramine (15 mg/kg) were also maintained. Behavioral and physiological parameters in open field and elevated plus maze were recorded. HECM showed dose-dependent reversal of OBX-induced physiological effects such as reduction of body weight, body temperature, heart rate and serum sodium concentration. HECM also showed reversal effects on OBX induced food intake increase and hyperactivity in open field and elevated plus maze paradigm. In conclusion, HECM demonstrated restorative effects in OBX induced depression model in rats probably due to stress reliving mechanisms.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100041
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-8913201502627
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.58 n.1 2015
Fonte: | info:eu-repo/semantics/openAccess