Data/hora: 16/06/2024 09:09:01

Provedor de dados: | 52
País: | Brazil
Título: | A model for the study of skeletal anomalies in rat fetuses
Autores: | Effting,Cristiane; Paula,Daniel Jesus de; Nunes Junior,Guilhermino Pereira.
Data: | 2004-03-01
Ano: | 2004
Palavras-chave: | Azol Antifungals; Ketoconazole; Models; Pregnancy; Skeletal Malformation; Steroids; Teratogenesis; Wistar Rats.
Resumo: | The aim of this study was to validate a model of skeletal anomalies in rat fetuses by the administration of ketoconazole (80 mg/kg) to pregnant rats during organogenesis. Bones of the head, trunk and anterior and posterior limbs were examined for detection of anomalies. Statistical differences regarding the number of fetuses and postimplantation resorptions, and fetal and placental weight were significant. The frequency of skeletal anomalies in the head, trunk, and anterior and posterior limbs in the ketoconazole-treated group were also significant when compared to the control group. It could be concluded that the model suggested was valid for study of skeletal anomalies and abnormal bones development in rat fetuse, in spite of the loss of fetuses due to resorptions.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000100005
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132004000100005
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.47 n.1 2004
Fonte: | info:eu-repo/semantics/openAccess