Data/hora: 09/06/2024 09:49:11

Provedor de dados: | Brazilian Archives of Biology and Technology
País: | Brazil
Título: | The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam
Autores: | Slomp Junior,Helvo; Seniski,Gerusa; Cunha,Cláudio da; Audi,Elizabeth Aparecida; Andreatini,Roberto.
Data: | 2010-12-01
Ano: | 2010
Palavras-chave: | Amnesic; Benzodiazepine; Memory; Mice; Phytotherapy.
Resumo: | The effect of a compound combining Valeriana officinalis and Passiflora alata extracts was tested on two mouse memory models: habituation and step-through inhibitory avoidance. Diazepam (1.0 and 2.5 mg/kg) was used as a positive control. Acute diazepam (2.5 mg/kg) before training impaired the habituation and performance in the inhibitory avoidance. On the other hand, acute phytotherapeutic compound (40-160 mg/kg), also before the training session, did not alter mouse behavior in these models. Repeated (15 days) treatment with the compound also did not impair the habituation. At the doses used, no locomotor effect was found. Taken together, the results suggest that, contrary to diazepam, the anxiolytic Valeriana officinalis and Passiflora alata compound did not induce amnesia.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600010
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132010000600010
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.53 n.6 2010
Fonte: | info:eu-repo/semantics/openAccess