Data/hora: 16/06/2024 08:44:21

Provedor de dados: 	52	
País: 	Brazil	
Título: 	Moxidectin interference on motor activity of rats	
Autores: 	Rodrigues-Alves,Patrícia de Sá e Benevides; Flório,Jorge Camilo; Lebrun,Ivo; Bernardi,Maria Martha; Spinosa,Helenice de Souza.	
Data: 	2009-08-01	
Ano: 	2009	
Palavras-chave: 	Moxidectin; GABA; Motor coordination; Rat; Open field; Wooden beam.	
Resumo: 	The present study investigated the effects of t moxidectin (MXD) in some parameters of rat motor function and neurochemical. The general activity in the open field and the motor coordination in the wooden beam were employed to evaluate the MXD effects. The results showed that, in the open field, even at high doses (2.0 and 20.0 mg/kg), the MXD did not alter the locomotion and the rearing frequencies. However, MXD was able to impair the motor coordination of the animals at wooden beam. Neurochemical studies of striatal GABA and dopamine neurotransmitters showed a reduced levels of dopamine and its metabolite, homovanillic acid, without interference on striatal GABA levels. Since GABAergic receptor stimulation had an inhibitory effect on dopaminergic striatal system, the decreased motor coordination could be attributed to an action of MXD on dopamine system via GABA activation.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400012	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/S1516-89132009000400012	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.52 n.4 2009	
Fonte: 	info:eu-repo/semantics/openAccess