Data/hora: 04/06/2024 03:46:07

Provedor de dados: | 52
País: | Brazil
Título: | Effect of indomethacin on the pregnant rat
Autores: | Damasceno,Débora Cristina; Volpato,Gustavo Tadeu; Ferrari,Cássio; Roldan,Luciana B.; Souza,Maricelma da Silva Soares.
Data: | 2008-02-01
Ano: | 2008
Palavras-chave: | Indomethacin; COX; Pregnancy; Rat; Implantation.
Resumo: | The objective of this study was to evaluate the reproductive performance, liver morphological study and post mortem characteristics of the pregnant Wistar rats treated with indomethacin, a general COX inhibitor. Indomethacin at doses of 0 (control), 0.32, 1.68 and 8.40 mg/kg/day were orally given once daily to each group (n=10) on days 3 and 4 of pregnancy (day 0 = first day of pregnancy = positive vaginal sperm). The animals were euthanized under anesthesia on day 11 of pregnancy, and were carried out necropsy and microorganism culture study. The results showed that the doses of 0.32 and 1.68 mg/kg body weight (the therapeutic dose for humans) of indomethacin caused no embryotoxic or lethal effects. The highest dose (8.40 mg/kg) of indomethacin disturbed implantation process and, thus, interrupted major development in some fetuses. The peritonitis was detected in the necropsy and in the bacteriological study of the animals treated with 8.4 mg/kg. It was considered death cause of these animals. Thus, this study analyzed a pharmacological agent on pregnancy in rodents and it provided some evidences that indomethacin presented embryotoxic and lethal effects at a high dose, but it was safe in the therapeutic dose used for humans.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000100010
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132008000100010
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.51 n.1 2008
Fonte: | info:eu-repo/semantics/openAccess