Data/hora: 08/06/2024 06:34:01

Provedor de dados: 	52	
País: 	Brazil	
Título: 	Antinociceptive and Anti-inflammatory Activities of Marine Sponges Aplysina Caissara, Haliclona sp. and Dragmacidon Reticulatum	
Autores: 	Hort,Mariana Appel; Silva Júnior,Flavio Manoel Rodrigues da; Garcia,Edariane Menestrino; Peraza,Gianni Goulart; Soares,Andrea; Lerner,Clea; Muccillo-Baisch,Ana Luiza.	
Data: 	2018-01-01	
Ano: 	2018	
Palavras-chave: 	Inflammation; Nociception; Marine sponges.	
Resumo: 	ABSTRACT Marine sponges are a rich source of bioactive natural products with multiple pharmacological properties. In this study, the anti-inflammatory and antinociceptive effects of extracts obtained from Aplysina caissara, Haliclona sp. and Dragmacidon reticulatum were evaluated by using the writhing test and formalin-induced mouse paw edema model in mice. All extracts were administered via oral pathway in the doses of 60 and 90 mg/kg. In the writhing test the pre-treatment with all sponges resulted in significant inhibition of the acetic acid-induced response, suggesting an antinociceptive effect. The formalin test showed that the extracts from A. caissara, Haliclona sp. and D. reticulatum, in the tested doses, did not affect the first formalin phase, however, they were effective in the late phase. To assess the potential anti-inflammatory activity of the extracts, the test of formalin-induced paw edema was used. The oral administration of A. caissara, Haliclona sp. and D. reticulatum extracts significantly reduced the formalin-induced paw edema in mice. In conclusion, our data show that marine sponges can be an important source of anti-inflammatory and antinocicpetive products that can be promising therapeutical leads. Furthermore, pharmacological and chemical studies have been developed not only to characterize the mechanism(s) that is/are responsible for the antinociceptive and anti-inflammatory action but also to identify the active principles of sponges.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100433	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/1678-4324-2018180104	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.61 2018	
Fonte: 	info:eu-repo/semantics/openAccess