Data/hora: 08/06/2024 15:44:14

Provedor de dados: | Brazilian Archives of Biology and Technology
País: | Brazil
Título: | Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride
Autores: | Fernandes,Mileni da Silva; Iano,Flávia Godoy; Rocia,Vivian; Yanai,Marcela Mitsuko; Leite,Aline de Lima; Furlani,Tatiana Almeida; Buzalaf,Marília Afonso Rabelo; Oliveira,Rodrigo Cardoso de.
Data: | 2011-12-01
Ano: | 2011
Palavras-chave: | Alkaline phosphatase; Fluoride; Liver; Kidney.
Resumo: | The aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p&lt;0.05). This study suggested that F at a concentration of 50 ppm in drinking water promotes increased the activity of alkaline phosphatase in the liver and blood plasma.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132011000600014
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.54 n.6 2011
Fonte: | info:eu-repo/semantics/openAccess