Data/hora: 05/06/2024 10:46:14

Provedor de dados: | 52
País: | Brazil
Título: | Evaluation of cytotoxicity and biological activities in extracellular polysaccharides released by cyanobacterium Arthrospira platensis
Autores: | Challouf,Rafika; Trabelsi,Lamia; Ben Dhieb,Rym; El Abed,Omeya; Yahia,Ali; Ghozzi,Khamissa; Ben Ammar,Jihen; Omran,Hela; Ben Ouada,Hatem.
Data: | 2011-08-01
Ano: | 2011
Palavras-chave: | Cyanobacteria; Exoplysaccharides; Cytotoxicity; Antibacterial; Antioxidant; Activity.
Resumo: | The aim of this work was to evaluate the cytotoxicity of Arthrospira platensis Extracellular Polymeric Substances (EPS) for colon cancer and kidney cell lines. Results showed that EPS were free from cytotoxic effects. A variety of solvents were assessed for their ability to extract the bioactive ingredients from EPS. Methanol gave the highest yield (75.75%) than other solvents. The extracts were tested for activities against a collection of Gram+/- bacteria. The methanol extract exhibited a more potent activity than the other organic extracts, whereas the aqueous extract was active against Staphylococcus epidermis (Gram+) and Salmonella typhimurium (Gram-). Finally, The extracts were also tested for the antioxidant activity, using the Trolox Equivalent Antioxidant Activity assay. The methanol extract displayed a moderate antioxidant activity (TEAC = 0.027 mg/ml). The HPLC analysis of this extract revealed two distinct peaks: 8.1 kDa (8.31 min) and 4.1 kDa (8.54 min).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000400024
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132011000400024
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.54 n.4 2011
Fonte: | info:eu-repo/semantics/openAccess