Data/hora: 16/06/2024 09:43:02

Provedor de dados: | 52
País: | Brazil
Título: | Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
Autores: | Guimarães,Fernando; Schanoski,Alessandra Soares; Cavalcanti,Tereza Cristina Samico; Juliano,Priscila Bianchi; Viera-Matos,Ana Neuza; Rettori,Ovídio.
Data: | 2010-10-01
Ano: | 2010
Palavras-chave: | Tumor growth rate; Spontaneous tumor regression; Wistar rats; Walker 256.
Resumo: | The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p&lt;0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132010000500014
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.53 n.5 2010
Fonte: | info:eu-repo/semantics/openAccess