Data/hora: 08/06/2024 10:32:37

Provedor de dados: | 52
País: | Brazil
Título: | Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
Autores: | Graça,José Ronaldo Vasconcelos; Bezerra,Mirna Marques; Lima,Vilma; Rodrigues,José Ariévilo Gurgel; Monteiro,Diego Levi Silveira; Quinderé,Ana Luíza Gomes; Amorim,Rodrigo César das Neves; Paula,Regina Célia Monteiro de; Benevides,Norma Maria Barros.
Data: | 2011-10-01
Ano: | 2011
Palavras-chave: | Halymenia floresia; Sulfated polysaccharides; Gut motility.
Resumo: | The aim of this work was to study the effect of Halymenia floresia (Hf) on duodenum contractility, and on experimental protocols of gastric compliance (GC) in rats. Fraction Hf2s exhibited a concentration-dependent myocontractile effect (EC50 12.48 µg/ml), and an inhibitory effect after consecutive washing. The contractile response promoted by Hf2s in the duodenum strips was completely inhibited by verapamil, and the effects were prevented in the presence of Ca2+-free medium. The pretreatment with atropine prevented the Hf2s myocontractile effect. Hf2s was also capable to decrease the GC (from 3.8±0.06 to 3.4±0.13 ml, P&lt;0.05), which did not return to basal levels after more 50 min of observation. These results indicated that the algal polysaccharide possessed in vitro and in vivo gastrointestinal effects.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132011000500008
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.54 n.5 2011
Fonte: | info:eu-repo/semantics/openAccess