Data/hora: 02/06/2024 16:36:08

Provedor de dados: | Brazilian Archives of Biology and Technology
País: | Brazil
Título: | Evaluation of different adjuvants formulations for bluetongue vaccine
Autores: | Macedo,Ludmila Branco; Lobato,Zélia Inês Portela; Fialho,Sílvia Ligório; Viott,Aline de Marco; Guedes,Roberto Maurício Carvalho; Silva-Cunha,Armando.
Data: | 2013-12-01
Ano: | 2013
Palavras-chave: | Emulsion; Microemulsion; Vaccine adjuvants; Immunology; Biocompatibility.
Resumo: | This study investigated the adjuvant potential of W/O/W multiple emulsions and microemulsions, comparing them with traditional aluminum hydroxide and oil-in-water emulsion adjuvants against bluetongue vaccine (BTV). Local inflammatory reactions were assessed in rabbits by measuring the temperature of the animals and the skin thickness at the site of application. Antibodies titers were determined by serum-neutralization test. Histological analyses of lesions at the site of adjuvants application were done. Results showed that multiple emulsion and microemulsion maintained their stability even in the presence of complex components and presented adequate characteristics for subcutaneous administration. They were able to induce immune response against BTV, but it was smaller than the traditional adjuvants. Despite microemulsion adjuvant showed lower antibodies titre, it was easier to prepare more stable at 4°C and it was the only one that did not induce any local reaction.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000600007
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132013005000002
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.56 n.6 2013
Fonte: | info:eu-repo/semantics/openAccess