Data/hora: 08/06/2024 16:32:22

Provedor de dados: 	Brazilian Journal of Infectious Diseases	
País: 	Brazil	
Título: 	Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital	
Autores: 	Morfin-Otero,Rayo; Garza-Gonzalez,Elvira; Aguirre-Diaz,Sara A.; Escobedo-Sanchez,Rodrigo; Esparza-Ahumada,Sergio; Perez-Gomez,Hector R.; Petersen-Morfin,Santiago; Gonzalez-Diaz,Esteban; Martinez-Melendez,Adrian; Rodriguez-Noriega,Eduardo.	
Data: 	2016-02-01	
Ano: 	2016	
Palavras-chave: 	Clostridium difficile; Outbreak; 027 strain; Mexico.	
Resumo: 	Abstract  Background Clostridium difficile infections caused by the NAP1/B1/027 strain are more severe, difficult to treat, and frequently associated with relapses.  Methods A case–control study was designed to examine a C. difficileinfection (CDI) outbreak over a 12-month period in a Mexican hospital. The diagnosis of toxigenic CDI was confirmed by real-time polymerase chain reaction, PCR (Cepheid Xpert C. difficile/Epi).  Results During the study period, 288 adult patients were evaluated and 79 (27.4%) patients had confirmed CDI (PCR positive). C. difficilestrain NAP1/B1/027 was identified in 31 (39%) of the patients with confirmed CDI (240 controls were included). Significant risk factors for CDI included any underlying disease (p &lt; 0.001), prior hospitalization (p &lt; 0.001), and antibiotic (p &lt; 0.050) or steroid (p &lt; 0.001) use. Laboratory abnormalities included leukocytosis (p &lt; 0.001) and low serum albumin levels (p &lt; 0.002). Attributable mortality was 5%. Relapses occurred in 10% of patients. Risk factors for C. difficileNAP1/B1/027 strain infections included prior use of quinolones (p &lt; 0.03). Risk factors for CDI caused by non-027 strains included chronic cardiac disease (p &lt; 0.05), chronic renal disease (p &lt; 0.009), and elevated serum creatinine levels (p &lt; 0.003). Deaths and relapses were most frequent in the 027 group (10% and 19%, respectively).  Conclusions C. difficile NAP1/BI/027 strain and non-027 strains are established pathogens in our hospital. Accordingly, surveillance ofC. difficile infections is now part of our nosocomial prevention program.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100008	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2015.09.008	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.20 n.1 2016	
Fonte: 	info:eu-repo/semantics/openAccess