Data/hora: 29/05/2024 02:38:29

Provedor de dados: | 55
País: | Brazil
Título: | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis
Autores: | Façanha,Mônica C.; Gondim,Argina M.B.; Pinheiro,Valéria G.F.; Barroso,Elizabeth C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A.M.
Data: | 2009-06-01
Ano: | 2009
Palavras-chave: | Tuberculosis; Bioavailability of antimycobacterial drugs; Intestinal barrier function; Rifampin; Isoniazid and pyrazinamide.
Resumo: | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p &lt; 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59) and 28% (12/59), respectively, in all individuals. The results demonstrated a marked decrease on intestinal paracellular transport in patients with active pulmonary tuberculosis and reduced serum concentrations of rifampin and isoniazid in both groups.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702009000300011
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.13 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess