Data/hora: 10/06/2024 13:52:45

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis	
Autores: 	Seyyedi,Noorossadat; Dehbidi,Gholamreza Rafiei; Karimi,Mozhgan; Asgari,Amir; Esmaeili,Babak; Zare,Farahnaz; Farhadi,Ali; Dabbaghmanesh,Mohammad Hossein; Saki,Forough; Behzad-Behbahani,Abbas.	
Data: 	2019-12-01	
Ano: 	2019	
Palavras-chave: 	Human herpesvirus 6; Prevalence; Hashimoto disease; Autoimmune diseases.	
Resumo: 	ABSTRACT  Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases.  Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated.  Methods: A total of 151 patients with clinically and laboratory confirmed HT, 59 patients with non-autoimmune thyroid disorders, and 32 patients with normal thyroid function were included in the study. For further confirmation of HT disease, all the precipitants were tested for anti-thyroid peroxidase (TPO), and anti-thyroglobulin (TG) antibodies. For detection of both HHV-6 types A and B, nested PCR and restriction enzyme digestion were used. HHV-6 DNA positive samples were further investigated by DNA sequencing analysis.  Results: HHV-6A DNA was found in serum sample of 57 out of 151 patients (38%) with HT, which was significantly more often than in patients with non-autoimmune thyroid disorders (p = 0.001). However, HHV-6 DNA was not detected in serum samples of euthyroid subjects.  Conclusions: The results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2019.10.004	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.23 n.6 2019	
Fonte: 	info:eu-repo/semantics/openAccess