Data/hora: 29/05/2024 02:50:03

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis
Autores: | Seyyedi,Noorossadat; Dehbidi,Gholamreza Rafiei; Karimi,Mozhgan; Asgari,Amir; Esmaeili,Babak; Zare,Farahnaz; Farhadi,Ali; Dabbaghmanesh,Mohammad Hossein; Saki,Forough; Behzad-Behbahani,Abbas.
Data: | 2019-12-01
Ano: | 2019
Palavras-chave: | Human herpesvirus 6; Prevalence; Hashimoto disease; Autoimmune diseases.
Resumo: | ABSTRACT  Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases.  Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated.  Methods: A total of 151 patients with clinically and laboratory confirmed HT, 59 patients with non-autoimmune thyroid disorders, and 32 patients with normal thyroid function were included in the study. For further confirmation of HT disease, all the precipitants were tested for anti-thyroid peroxidase (TPO), and anti-thyroglobulin (TG) antibodies. For detection of both HHV-6 types A and B, nested PCR and restriction enzyme digestion were used. HHV-6 DNA positive samples were further investigated by DNA sequencing analysis.  Results: HHV-6A DNA was found in serum sample of 57 out of 151 patients (38%) with HT, which was significantly more often than in patients with non-autoimmune thyroid disorders (p = 0.001). However, HHV-6 DNA was not detected in serum samples of euthyroid subjects.  Conclusions: The results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2019.10.004
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.23 n.6 2019
Fonte: | info:eu-repo/semantics/openAccess