Data/hora: 09/06/2024 18:23:50

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
Autores: | Antonello,Vicente Sperb; Appel-da-Silva,Marcelo Campos; Kliemann,Dimas Alexandre; Santos,Breno Riegel; Tovo,Cristiane Valle.
Data: | 2013-10-01
Ano: | 2013
Palavras-chave: | HIV; Hepatitis C; Coinfection; HAART; CD4; Immunological response.
Resumo: | OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency virus/hepatitis C virus coinfected patients. In the present study human immunodeficiency virus/hepatitis C virus coinfection did not seem to influence CD4 Tlymphocytes recovery. There was no difference between the curves of CD4 T-lymphocytes raise of coinfected and monoinfected groups. CONCLUSION: This prospective study confirms that hepatitis C virus infection does not seem to be associated with impaired CD4 T-lymphocytes recovery after HAART.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500007
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2013.01.015
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.17 n.5 2013
Fonte: | info:eu-repo/semantics/openAccess