Data/hora: 03/06/2024 18:46:47

Provedor de dados: | 55
País: | Brazil
Título: | Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
Autores: | Alves,Crésio; Oliveira,Ana Cláudia; Brites,Carlos.
Data: | 2008-08-01
Ano: | 2008
Palavras-chave: | HIV; Lipodystrophy; Highly active antiretroviral treatment; Children and adolescents.
Resumo: | The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohipertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohipertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some mechanisms have been described, including leptin and adiponectin deficiency, mitochondrial dysfunction and use of antiretroviral drugs. The type, dose and duration of the antiretroviral treatment, as well as age and puberty are the main risk factors. LS is also associated with increased incidence of cardiovascular illnesses, atherosclerosis and diabetes mellitus. Treatment includes physical activity, cautious restriction of caloric intake, changes in antiretroviral therapy, and use of insulin-sensitizing and lipid-lowering agents. Follow up must be periodic, consisting of measurement of body fat distribution, evaluation of the lipid profile and insulin resistance.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400018
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702008000400018
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.12 n.4 2008
Fonte: | info:eu-repo/semantics/openAccess