Data/hora: 13/06/2024 21:43:05

Provedor de dados: 	55	
País: 	Brazil	
Título: 	HCV virological response during treatment of chronic hepatitis C is associated with liver histological Improvement in patients with HCV/HIV co-infection	
Autores: 	Castro,Gleusa; Ramalho,Leandra Naira Zambelli; Zucoloto,Sérgio; Martinelli,Ana de Lourdes Candolo; Figueiredo,José Fernando de Castro.	
Data: 	2008-06-01	
Ano: 	2008	
Palavras-chave: 	Chronic hepatitis C; Hepatic stellate cell; Histological response; Human immunodeficiency virus; Paired liver biopsies.	
Resumo: 	Liver histological improvement after treatment for chronic hepatitis C in patients co-infected with human immunodeficiency virus-1 (HIV-1) has been described. Paired liver biopsies in twenty six HCV/HIV co-infected patients were compared to determine factors possibly associated with histological improvement. The patients were submitted to a liver biopsy before treatment for hepatitis C and 25 months after the end of treatment. Fragments of the liver biopsy obtained before and after treatment were compared regarding the following parameters: histological activity index (HAI) and degree of fibrosis (Knodell); intensity of collagen deposits (Sirius Red staining) and degree of stellate cell activation (alpha-smooth muscle actin labeling). The ratios of the post and pre-treatment variables were related through logistic regression to body mass index (BMI), alcohol ingestion, HCV genotype, HCV viremia, presence of hepatic iron and pre-treatment hepatic steatosis. A negative RNA test in the 24th week of treatment was associated with improvement in fibrosis, collagen deposits and stellate cell numbers. The other variables analyzed did not correlate to an improvement in hepatic histology after hepatitis C treatment. Reduction in HCV viremia during treatment may result in reduced hepatic fibrosis even in patients without a sustained virological response.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300004	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702008000300004	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.12 n.3 2008	
Fonte: 	info:eu-repo/semantics/openAccess