Data/hora: 02/06/2024 06:21:36

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Short-interfering RNAs as antivirals against rabies	
Autores: 	Brandão,Paulo Eduardo; Castilho,Juliana Galera; Fahl,Willian; Carnieli Jr.,Pedro; Oliveira,Rafael de Novaes; Macedo,Carla Isabel; Carrieri,Maria Luiza; Kotait,Ivanete.	
Data: 	2007-04-01	
Ano: 	2007	
Palavras-chave: 	SiRNA; Rabies; Antiviral.	
Resumo: 	This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702007000200011	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.11 n.2 2007	
Fonte: 	info:eu-repo/semantics/openAccess