Data/hora: 04/06/2024 04:23:20

Provedor de dados: | 55
País: | Brazil
Título: | A SYSTEMATIC REVIEW ON THE INFLUENCE OF HLA-B POLYMORPHISMS ON HIV-1 MOTHER-TO-CHILD-TRANSMISSION
Autores: | Angulo,Juan Manuel Cubillos; Cuesta,Taryn Ariadna Castro; Menezes,Eliane Pereira; Pedroso,Celia; Brites,Carlos.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | "Mother to child transmission"; "HIV"; "HLA-B".
Resumo: | ABSTRACT  Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.  Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT.  Methods: Two independent reviewers performed a systematic review on search engines PubMed, Europe PMC, Cochrane, Scientific Electronic Library Online (SciELO), and Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs), using the following key terms: "HIV infection", "HIV newborn", "HLA polymorphisms", "HLA-B", and "Mother to child transmission". All studies focusing on evaluation of HIV-1 MTCT, HIV infection evolution, and molecular analyses of HLA-B in children were selected.  Results: Nine studies fulfilled the inclusion criteria. Sixteen HLA-B alleles groups were associated with HIV-1 infection; seven of them (43.8%) were related to slow disease progression or reduced risk of MTCT, while six (37.5%) alleles groups were linked to a faster progression of HIV infection in children and to increased risk of MTCT. The available evidence suggest that HLA-B*57 group allele is associated with slow disease progression, while HLA-B*35 group allele is associated to increased risk of MTCT and rapid disease progression in infected children. The role of HLA-B*18, B*58 and B*44 are still controversial because they were associated to both, protection against MTCT, and to higher HIV replicative capacity, in different studies.  Conclusion: HLA-B*57 group allele can be protective against MTCT while HLA-B*35 groups alleles are consistently associated with HIV-1 MTCT.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100053
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2018.12.002
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.23 n.1 2019
Fonte: | info:eu-repo/semantics/openAccess