Data/hora: 09/06/2024 08:23:27

Provedor de dados: | 55
País: | Brazil
Título: | Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
Autores: | Nogueira,Keite da Silva; Daur,Alessandra Vale; Reason,Iara Taborda de Messias; Gales,Ana Cristina; Costa,Libera Maria Dalla.
Data: | 2011-04-01
Ano: | 2011
Palavras-chave: | Enterobacteriaceae; Beta-lactamases; Cephalosporin resistance.
Resumo: | The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone &amp;gt; 21 and MIC &lt; 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were &lt; 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702011000200014
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.15 n.2 2011
Fonte: | info:eu-repo/semantics/openAccess