Data/hora: 09/06/2024 15:36:58

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder
Autores: | Carneiro Neto,Jose Abraão; Santos,Silvane Braga; Orge,Gloria Orge; Tanajura,Davi; Passos,Lucia; Oliveira,Cassius José; Andrade,Rosana; Melo,Cláudio Galeno de; Barroso Jr,Ubirajara; Carvalho,Edgar M.
Data: | 2018-03-01
Ano: | 2018
Palavras-chave: | Overactive bladder; Onabotulinum toxin; HTLV-1.
Resumo: | ABSTRACT  Aim: To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL).  Methods: Case series with 10 patients with overactive bladder refractory to conservative treatment with anticholinergic or physical therapy. They received 200Ui of onabotulinumtoxin type A intravesically and were evaluated by overactive bladder symptoms score (OABSS) and King's Health Questionnaire.  Results: The mean (SD) of the age was 52 + 14.5 years and 60% were female. All of them had confirmed detrusor overactivity on urodynamic study. Seven patients had HAM/TSP. The median and range of the OABSS was 13 (12–15) before therapy and decreased to 1.0 (0–12) on day 30 and to 03 (0–14) on day 90 (p &lt; 0.0001). There was a significant improvement in 8 of the 9 domains of the King's Health Questionnaire after the intervention. Hematuria, urinary retention and urinary infection were the complications observed in 3 out of 10 patients. The mean time to request retreatment was 465 days.  Conclusion: Onabotulinum toxin type A intravesically reduced the OABSS with last long effect and improved the quality of life of HTLV-1 infected patients with severe overactive bladder.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200079
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2017.10.009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.22 n.2 2018
Fonte: | info:eu-repo/semantics/openAccess