Data/hora: 02/06/2024 16:00:45

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae
Autores: | Nicodemo,A.C.; Mendes,C.M.F.; Oplustil,C.P.; Sinto,S.
Data: | 2001-04-01
Ano: | 2001
Palavras-chave: | S. pneumoniae antimicrobial resistance; Susceptibility testing in vitro; Respiratory tract infections; Pneumococci.
Resumo: | In recent years, the level of resistance of S. pneumoniae to beta-lactam and/or macrolides has increased around the world including some countries in South America. Because of this resistance, it is necessary to test the therapeutic alternatives for treating this pathogen, including the newer quinolones. This study was carried out in order to compare the in vitro activity of fluoroquinolones gatifloxacin, levofloxacin and trovafloxacin, to penicillin G, amoxicillin, amoxicillin-clavulanate, cufuroxime sodium, ceftriaxone, azithromycin and clarithromycin, against 300 strains of S. pneumoniae. Of the 300 samples tested, 18.6% were not susceptible to penicillin (56 strains) and 7% (21 strains) were resistant to the second generation cephalosporin. Among the macrolides, resistance ranged from 6.7% for clarithromycin to 29.6% for azithromycin. Susceptibility to the newer quinolones was 100% including the 56 strains not susceptible to penicillin. Among the 10 antibiotics evaluated, the fluoroquinolones gatifloxacin, levofloxacin, and trovafloxacin displayed high levels of in vitro activity against S. pneumoniae.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200001
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702001000200001
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.5 n.2 2001
Fonte: | info:eu-repo/semantics/openAccess