Data/hora: 28/05/2024 16:26:51

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study	
Autores: 	Palchetti,Cecília Zanin; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Patin,Rose Vega; Teixeira,Patrícia Fonseca; Machado,Daisy Maria; Oliveira,Fernanda Luisa Ceragioli.	
Data: 	2015-12-01	
Ano: 	2015	
Palavras-chave: 	HIV; Child; Body composition; Bone mineral density.	
Resumo: 	ABSTRACT  OBJECTIVE:  To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass.  METHODS:  A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal.  RESULTS:  Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content (BMC) (p = 0.001), TBMD (p = 0.006) and LSBMD (p = 0.002) compared to prepubertal patients. After multivariate linear regression analysis, the predictors of bone mass in T1 were age, BMI and HAZ-scores for BMC; BMI Z-score, adequate serum magnesium concentration and dietary calcium intake for TBMD; adequate serum concentration of magnesium, BMI and HAZ-scores for LSBMD. In T2, age, total body fat and lean body mass (kg) for BMC; BMI Z-score and puberty for TBMD; dietary fat intake, BMI Z-score for BMD and puberty for LSBMD.  CONCLUSION:  HIV-infected children have compromised bone mass and the presence of puberty seems to provide suitability of these parameters. Adequate intake of calcium and fat appears to be protective for proper bone mass accumulation factor, as well as monitoring nutritional status and serum magnesium concentration.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2015.08.010	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.19 n.6 2015	
Fonte: 	info:eu-repo/semantics/openAccess