Data/hora: 10/06/2024 13:33:42

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma
Autores: | Caterino-de-Araujo,Adele; Santos-Fortuna,Elizabeth de los; Carbone,Paulo Henrique Lage; Cibella,Sandra Elisa Lopes; Moreira,Abdiel Aparecido.
Data: | 2003-12-01
Ano: | 2003
Palavras-chave: | Human herpesvirus - 8 (HHV-8) anti-lytic and anti-latent antibodies; HHV-8 infection in women; HHV-8 in HIV-1 infected women; HHV-8 seroprevalence; HHV-8 infection; Kaposi's sarcoma (KS).
Resumo: | BACKGROUND: With the spread of AIDS, many HIV-infected women have been diagnosed with Kaposi's sarcoma (KS), especially in Africa. Since the discovery of a novel herpesvirus as the causative agent of KS (human herpesvirus 8 - HHV-8) several seroepidemiological studies have been conducted to identify groups at risk for KS. The risk for women in Brazil has not been studied. MATERIALS AND METHODS: We searched for HHV-8 antibodies in sera obtained from a bank made up of samples from 3 groups of individuals: Group I: 163 HIV-1-infected women attended at an ambulatory clinic in 1994; Group II: 108 children born to HIV-1-infected mothers from 1990 to 1992, their antibodies reflected maternal infection, and Group III: 630 HIV-1-seronegative, healthy women. In-house immunofluorescence and Western-Blot assays based on the BCBL-1 cell line were used to detect anti-latent and anti-lytic HHV-8 antibodies. RESULTS: Group I had an overall frequency of antibodies of 8.6%, with a 1.2% frequency of anti-latent antibodies and an 8.0% frequency of anti-lytic antibodies. Similar results were detected in Group II, i.e., no cases with anti-latent antibodies and a 7.4% frequency of anti-lytic antibodies. In contrast, prevalences of 1.1% anti-latent antibodies and 0.3% anti-lytic antibodies were observed in Group III. CONCLUSIONS: The epidemiologic pattern of HHV-8 in women from São Paulo varies according to behavioral factors, with emphasis on the sexual and blood routes of virus transmission/acquisition. Although HHV-8 anti-lytic antibodies were found in HIV-1-infected women, no case of KS was detected. Protective factors against KS are probably related to gender and/or to antiretroviral therapies introduced in Brazil since 1994.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600007
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702003000600007
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.7 n.6 2003
Fonte: | info:eu-repo/semantics/openAccess