Data/hora: 08/06/2024 14:22:55

Provedor de dados: | 55
País: | Brazil
Título: | Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice
Autores: | Amini,Marzyeh; Nahrevanian,Hossein; Khatami,Shohreh; Farahmand,Mahin; Mirkhani,Fatemeh; Javadian,Seifoddin.
Data: | 2009-04-01
Ano: | 2009
Palavras-chave: | Balb/c; C57bl/6; CL; Iran; Leishmania major; Treatment; Cu; Zn.
Resumo: | Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in infected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with susceptibility/resistance to Leishmania major in Balb/c and C57bl/6 mice. We detected Zn deficiency in the plasma of infected Balb/c mice; possibly, therapeutic administration of Zn would be useful for treating this form of leishmaniasis. Increases in Cu level might increase resistance to leishmaniasis. Based on our findings, the Cu/Zn ratio could be a useful marker for the pathophysiology of leishmaniasis.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200002
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702009000200002
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.13 n.2 2009
Fonte: | info:eu-repo/semantics/openAccess